阿魏酸钠治疗慢性肾小球肾炎30例临床观察

目的: 观察阿魏酸钠治疗慢性肾小球肾炎的疗效。方法: 将56例慢性肾小球肾炎患者随机分为治疗组30例,应用阿魏酸钠治疗,对照组26例应用肌苷及维生素B₆。21天后评价疗效。结果: 两组疗效、症状消失时间(除血尿外)、血浆比黏度、24 h尿蛋白定量、内生肌酐清除率(Ccr)和血肌酐(Scr)差异均有显著性(P<0.05~P<0.01)。结论: 阿魏酸钠可改善血液高凝状态,减少蛋白尿,降低血压,减少血管内皮损伤,改善慢性肾小球肾炎预后,对肾功能有一定保护作用。

Effects of sodium ferulate on chronic glomerulonephritis:A report of 30 cases

Objective:To observe the effect of sodium ferulate in treatment of chronic glomerulonephritis.Methods:Fifty-six cases of chronic glomerulonephritis were randomly divided into treatment group(30 cases) and control group(26 cases).The treatment group were administered sodium ferulate and the controls received guttae intravenously and vitamin B 6.The curative effect was evaluated after 21 days.Results:There was significant difference between the two groups in the time of symptom disappearing,the plasma contrast viscosity,24 h urine protein quantization and creatinine clearance rate(Ccr) and serum creatinine(Scr)(P<0.05 to P< 0.01).Conclusions:Sodium ferulate can improve the blood hypercoagulation state; reduce the content of urine protein,lower the blood pressure and minimize the injury of vascular endothelium.It may protect the renal function to a certain extent and improve the prognosis of chronic glomerulonephritis.