| 选择性IgA缺乏症的部分细胞因子研究 |
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| 引用本文： | 宋淑媛,邓士芳,李京华. 选择性IgA缺乏症的部分细胞因子研究[J]. 中国儿童保健杂志, 1996, 0(2) |
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| 作者姓名： | 宋淑媛 邓士芳 李京华 |
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| 作者单位： | 北京儿科研究所 100045(宋淑媛，邓士芳)，北京儿科研究所 100045(李京华) |
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| 摘 要： | 为探讨白细胞介素及白细胞介素受体在选择性IgA缺乏症发病过程中的作用,我们采用间接免疫荧光技术、ELISA夹心法及细胞培养,分别对15例患儿及对照组进行了T细胞亚群、Tac阳性细胞(mIL—2Rα)百分率、SIL—2R及IL—4含量检测。发现SIgAD患儿Tac阳性细胞(mIL—2Rα百分率及血清SIL—2R明显高于对照组,CD4、CD4/CD8、IL—4水平则显著低于对照组。表明血资SIL—2Rα异常增高不但可抑制IL—2的生物活性,还可反馈性地使其它免疫调节相关因子,如IL—4生成受阻。
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| 关 键 词： | 选择性IgA缺乏症 白细胞介素 白细胞介素受体 |
A STUDY ON INTERLEUKIN-2 RECEPTORS AND INTERLEUKIN-4 IN CHILDREN WITH SELECTIVE IgA DEFICIENC |
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| Song Shuai,et al. A STUDY ON INTERLEUKIN-2 RECEPTORS AND INTERLEUKIN-4 IN CHILDREN WITH SELECTIVE IgA DEFICIENC[J]. Chinese Journal of Child Health Care, 1996, 0(2) |
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| Authors: | Song Shuai et al |
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| Affiliation: | Beijing Pediatric Research Institute |
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| Abstract: | In order to clarify possible roles of interleukin-2 receptor-(IL-2R)and interleukin-4 in pathogenesis of selective IgA deficiency (SIgAD), we detected the percentage of CD3,CD4, CD8and activated T Lymphocytes expressing IL-2R on the membrane with immunofluorescence, Serum IL-2with a sandwich ELISA and IL-4 in the culture media of peripheral mononuclear cells with an ELISA in 15 children with SIgAD and 15 normal controls. The results showed that the percentage of activated T cell positive for membrane IL-2R and serum IL-2R level were significantly higher than those of control group;while the CD4,CD4/CD8 and serum IL-4 level lever was significantly lower in SIgAD group than in the control group. These results suggest that the marked increase of serum IL-2 may not only inhibit the bioactivity of IL-2,but also down regulate generation of relevant cytokines such as IL-4 through a feedback effect. |
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| Keywords: | Selective IgA deficiency Interleukin Interleukin receptor |
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