Rapid-eye-movement sleep deprivation inhibits clonidine-induced sedation in rats |
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Authors: | Ewa Mogilnicka Andrzej Pilc |
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Institution: | Institute of Pharmacology, Polish Academy of Sciences, 31-343 Kraków, Poland |
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Abstract: | The effects of 24 and 48 h of rapid-eye-movement sleep deprivation (REMD) on clonidine-induced sedation and 3H]clonidine binding to cortical membranes were studied in rats. REMD did not affect the exploratory behaviour (ambulation, rearing + peeping) of normal rats. The sedative effect of clonidine (0.2 mg/kg s.c.) on the rearing + peeping behaviour of rats was inhibited by REMD. 3H]Clonidine binding in the cerebral frontal cortex remained unaffected. The results are discussed in terms of changes in the noradrenegic system. |
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Keywords: | REM sleep deprivation Clonidine-induced sedation |
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