The action of morphine and naloxone on acid secretion by the rat isolated stomach |
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| Authors: | SPaul Canfield Jan Spencer |
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| Institution: | 1. Department of Physiology, St. Mary''s Hospital Medical School, London W2 1PG, UK;2. Department of Zoology, Westfield College, London NW3 7ST, U.K. |
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| Abstract: | The action of morphine and naloxone on acid secretion by the rat isolated stomach has been studied. Morphine (10?7 to 10?4 M) had no effect upon spontaneous acid secretion. Morphine (10?6 M) did not modify the acid output in response to sub-maximal stimulation by pentagastrin, histamine, bethanechol or isoprenaline. Naloxone (10?6 M) was without effect on the response to pentagastrin or histamine. Our results suggest that opiate receptors do not modify acid secretion in this preparation. |
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| Keywords: | Morphine Rat Naloxone Isolated Acid Stomach |
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