Acetylcholinesterase and cholinesterase activities in the mouse cerebellum following misonidazole treatment |
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| Authors: | Claire Clarke F Hobbiger PW Sheldon |
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| Institution: | 7. Radiobiology Unit, Department of Physics, Institute of Cancer Research, Sutton, Surrey SM2 5PX, England;71. Department of Pharmacology and Therapeutics, The Middlesex Hospital Medical School, London W1P 7PN, England |
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| Abstract: | The acetylcholinesterase and cholinesterase activities in the mouse cerebellum were unchanged following misonidazole treatment. Inhibition of acetylcholinesterase activity only occurred at concentrations of misonidazole which were in excess of those obtained clinically. These findings indicate that the clinical neurotoxicity of the drug cannot be attributed to an effect on cholinesterases. |
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| Keywords: | Misonidazole Acetylcholinesterase Cholinesterase |
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