罗格列酮对大鼠急性心肌缺血再灌注损伤的保护作用

目的：观察罗格列酮(RSG)对大鼠急性心肌缺血再灌注(I-R)损伤心肌梗死面积、心律失常发生率和心肌病理学改变的影响。方法：结扎大鼠左冠状动脉前降支30 min、再灌注120 min建立大鼠心肌I-R损伤模型，将大鼠随机分为I-R损伤模型组、RSG高剂量(6 mg•kg^-1)、低剂量(3 mg•kg^-1)组和假手术组，灌胃给药1周后行I-R损伤手术，观察心肌梗死面积、心律失常发生次数和类型、心肌组织学改变和心肌细胞超微结构的变化。结果：与模型组比较，RSG高剂量组心肌梗死面积与左心室面积百分率（IS/LV％,29.3±4.9 vs 37.6±3.2）以及心肌梗死面积与危险区面积比值(IS/AAR％,76.1±9.6 vs 93.5±7.4)减少（P<0.05或P<0.01）；RSG高量组心律失常评分（2.6±0.4）低于I-R损伤模型组（4.2±0.6）(P<0.05)。RSG组心肌病理组织学和心肌细胞超微结构损伤轻于I-R损伤模型组。结论：RSG可通过减少I-R损伤大鼠心肌梗死面积、减少恶性心律失常的发生及改善病理组织学损伤而起到对大鼠心肌I-R损伤的保护作用。

Protective effect of rosiglitazone on myocardial ischemia-reperfusion injury in rats

Objective To observe the effects of rosiglitazone(RSG) on myocardial infarct size(IS),incidence rate of arrhythmias and the pathohistological changes in rat model of acute myocardial ischemia-reperfusion(I-R) injury.Methods The rat myocardial I-R injury model was induced by ligating left anterior descending branch of coronary artery for 30 min and reperfusing for 120 min.Wistar rats were randomly divided into four groups: I-R group,RSG groups with the doses of 3 and 6 mg·kg-1,and sham-operation group.IS,times and types of arrhythmia,pathohistological changes of myocardium tissue and changes of myocardial cell ultrastructure were observed.Results Compared with I-R group,RSG decreased the ratio of IS/LV%(29.3±4.9 vs 37.6±3.2,P<0.05) and the rate of IS/AAR%(76.1±9.6 vs 93.5±7.4,P<0.05),reduced the score of arrhythmias(2.6±0.4 vs 46.2±0.6,P<0.05),the injuries of pathohistology of myocardium and myocardial cell ultrastructure in RSG group were better that those in IR group.Conclusion RSG has the protective effect on acute myocardial I-R injury in rats,probably by reducing myocardium ischemia area and incidence rate of arrhythmias and ameliorating morphology and ultrastructure of myocardium.