Benign extraaxial tumors: contrast enhancement with Gd-DTPA

Meningiomas, acoustic neuromas, and other benign extraaxial tumors have little contrast with adjacent brain tissue on conventional magnetic resonance (MR) images. The contrast enhancement produced by intravenous administration of 0.1 mmol/kg of gadolinium-DTPA in these tumors was measured on T1 MR images. Acoustic neuromas showed the greatest enhancement (average, 310%), meningiomas the next greatest (average, 180%), and neurofibromas, glomus tumors, and pituitary microadenomas the least enhancement. The degree of enhancement was almost always greater at 3 minutes than at 25 or 55 minutes. Contrast between the tumor and adjacent tissue resulted from tumor enhancement in neuromas, meningiomas, and neurofibromas and from enhancement of the surrounding tissue in pituitary microadenomas.