An Improved Method for the Preparation of Intermediate-Purity Antihemophilic Factor Concentrate for Therapeutic Usage |
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| Authors: | Daniel T. H. Liu J. F. Irwin R. O. LeFave B. Grzenczyk and R. C. Pai |
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| Affiliation: | Blood Process Research Department, Parke-Davis &Company, Rochester, Mich. |
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| Abstract: | Abstract. An improved method involving pH changes in the process for the preparation of intermediate-purity antihemophilic concentrate offers several advantages over the standard method. Antihemophilic concentrates thus prepared are more soluble, more purified and more stable than the standard antihemophilic concentrates. High-potency antihemophilic concentrates with good solubility may be obtained by concentrating the [in-process] solution before lyophilization. |
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