| 三叶因子2和环氧合酶-2在胃癌组织中的表达 |
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| 引用本文： | 石磊,赖铭裕,梁志海,刘诗权,黄杰安,唐国都,姜海行. 三叶因子2和环氧合酶-2在胃癌组织中的表达[J]. 实用医学杂志, 2011, 27(3): 411-413. DOI: 10.3969/j.issn.1006-5725.2011.03.019 |
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| 作者姓名： | 石磊 赖铭裕 梁志海 刘诗权 黄杰安 唐国都 姜海行 |
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| 作者单位： | 1. 广西医科大学第一附属医院老年消化内科,南宁市,530021
2. 广西医科大学第一附属医院消化内科,南宁市,530021 |
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| 基金项目： | 广西卫生厅自筹经费科研课题(编号:桂卫2008111) |
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| 摘 要： | 目的:研究三叶因子2(TFF2)和环氧合酶-2(COX-2)在正常胃黏膜组织、癌旁组织和胃癌组织中的表达情况,探讨TFF2表达与胃癌发生的关系。方法:采用SP免疫组化方法检测30例正常胃黏膜组织、50例癌旁组织和50例胃癌组织中TFF2和COX-2的表达。结果:正常胃黏膜组织→癌旁组织→胃癌组织中,TFF2表达呈逐渐减弱趋势(165.80±16.42,184.44±19.02和206.79±17.62,P<0.01),而COX-2的表达呈逐渐上升趋势(217.50±12.60,203.08±17.68和193.50±16.160,P<0.01),TFF2的表达强度与COX-2呈负相关(r=-0.761,P<0.01)。结论:COX-2的表达增加抑制TFF2的表达,细胞增殖与凋亡失衡,最终导致胃癌的发生。
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| 关 键 词： | 胃肿瘤 三叶因子2 环氧合酶-2 免疫组织化学 |
Expressions of trefoil factor 2 and cyclooxygenase-2 in gastric cancer |
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| SHI Lei,LAI Ming-yu,LIANG Zhi-hai,LIU Shi-quan,HUANG Jie-an,TANG Guo-du,JIANG Hai-xing. Expressions of trefoil factor 2 and cyclooxygenase-2 in gastric cancer[J]. The Journal of Practical Medicine, 2011, 27(3): 411-413. DOI: 10.3969/j.issn.1006-5725.2011.03.019 |
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| Authors: | SHI Lei LAI Ming-yu LIANG Zhi-hai LIU Shi-quan HUANG Jie-an TANG Guo-du JIANG Hai-xing |
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| Affiliation: | SHI Lei,LAI Ming-yu,LIANG Zhi-hai,LIU Shi-quan,HUANG Jie-an,TANG Guo-du,JIANG Hai-xing.Department of Geriatric Gastroenterology,First Affiliated Hospital,Guangxi Medical University,Guangxi 530021,China |
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| Abstract: | Objective To investigate the expressions of trefoil factor 2 (TFF2) and cyclooxygenase-2 (COX-2) in normal gastric mucosal tissues,paracancerous tissues,and gastric carcinoma tissues and to explore the association of TFF2 with carcinogenesis.Methods Expressions of TFF2 and COX-2 were determined by immunohistochemical assay in 30 specimens of normal gastric mucosal tissues,50 paracarcancerous tissues,and 50 carcinoma tissues.Results The expression level of TFF2 had a decreasing tendency in the normal tissues... |
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| Keywords: | Gastric neoplasms Trefoil factor 2 Cyclooxygenase-2 Immunohistochemistry |
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