多西他赛和顺铂同步放化疗治疗局部晚期鼻咽癌临床观察

目的观察局部晚期鼻咽癌同步放化疗的疗效及毒副反应。方法 70例局部晚期鼻咽癌,采用静脉化疗2周期,化疗方案：多西他赛75 mg/m2,分于第1,8天给药;顺铂（DDP）25 mg/（m2.d）d1-3天,21天为1周期。同时给予同步放疗,鼻咽部原发灶给予6 MV-X线和15 MV-X线DT 70 Gy～78 Gy/7-8周。结果 70例中CR 20例,PR 37例,总有效率81.4%。1年、3年生存率分别为98.4%、83.9%。主要毒副反应为骨髓抑制、急性口腔黏膜炎、恶心呕吐、皮肤反应。结论多西他赛和顺铂同步放化疗治疗局部晚期鼻咽癌疗效较好,毒副反应可以耐受。

Concurrent chemoradiotherapy with docetaxel and cisplatin in treatment of locally advanced nasopharyngeal carcinoma

Objective To assess the efficacy and toxicity of concurrent chemoradiotherapy with decetaxel and cisplatin in treatment of patients with locally advanced nasopharyngeal carcinoma.Methods Seventy patients with locally advanced nasopharyngeal carcinoma received vein chemotherapy of DP regimen(docetaxel 75 mg/m2 at d1 and d8;cisplatin 25 mg/m2 d1-3 for 21 d).All patients underwent concurrent radiotherapy by 6 MV X-ray and 15 MV X-ray with DT 70～78 Gy for 7-8 W.Results Among 70 patients,20 achieved CR and 37 PR with the effective rate of 81.4%;the 1,3 years survival rates were 98.4% and 83.9%,respectively.The main adverse effects were bone marrow depression,acute oral mucositis,nausea and vomiting,skin reactions.Conclusion Concurrent chemoradiotherapy with docetaxel and cisplatin is effective with less toxicities in treatment of patients with locally advanced nasopharyngeal carcinoma.