2型糖尿病患者臂踝脉搏波传播速度与微量白蛋白尿的关系

目的 探讨微量白蛋白尿（MAU）与2型糖尿病（T2DM）患者臂踝脉搏波传播速度（baPWV）之间的关系。方法 T2DM患者160例，男性84例，女性76例；根据尿白蛋白检测分成2组，即MAU组42例和正常白蛋白尿组（NAU组）118例。动脉硬化诊断仪测量baPWV。结果 MAU组年龄、血压、baPWV均较NAU组高（均P％0．05），MAU与baPWV正相关（r=0．58，P％0．05）。调整年龄、性别、体质量指数、心率、血压、血糖、血脂和糖基化血红蛋白后，多元逐步回归提示只有MAU与baPWV独立相关（SEB]=0．376，P％0．005）。结论 MAU与T2DM早期动脉粥样硬化相关。

The Relation between Brachial Ankle Pulse Wave Velocity and Microalbuminuria in Type 2 Diabetic Patients

Objective To investigate the relation between microalbuminuria and brachial ankle pulse wave velocity(baPWV) in type 2 diabetic patients.Methods A total of 160 type 2 diabetic patients(84 men and 76 women) were divided into two groups based whether the presence of microalbuminuria: group microalbuminuria(MAU,n=42) and group normoalbuminuria(NAU,n=118).PWV was measured with Japanese VS1000 artherosclerosis diagnometer.Results Group MAU was significantly older,more higher blood pressure and baPWV(P<0.05,respectively) than those of the patients with normoalbuminuria.Microalbuminuria was correlated positively with baPWV(r=0.58,P<0.05).Multivariate analysis,after adjustment with a series of confounding factors such as age,sex,body mass index,heart rate,blood pressure,plasma glucose,plasma lipids and HbA1c,demonstrated that only the presence of microalbuminuria was independently associated with baPWV(SE\=0.376,WTBX]P<0.005).Conclusion Microalbuminuria is correlated with early artherosclerosis in type 2 diabetes.