| CD4+CD25+和CD8+调节性T细胞的作用机制 |
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| 引用本文： | 欧媛,朱平. CD4+CD25+和CD8+调节性T细胞的作用机制[J]. 中国实验血液学杂志, 2005, 13(6): 1137-1140 |
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| 作者姓名： | 欧媛 朱平 |
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| 作者单位： | 北京大学第一医院血液内科,北京,100034 |
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| 摘 要： | 调节性T细胞（Treg）主要在机体免疫系统中发挥负向调节作用,既能抑制不恰当的免疫反应,又能限定免疫应答的范围、程度及作用时间,对CD4^＋和CD8^＋效应性T淋巴细胞的增殖起抑制作用,因此在移植物抗宿主病、自身免疫病、过敏性疾病等的发病机制和临床治疗中有潜在的应用价值.本文重点介绍CD4^＋CD25^＋Treg和CD8^＋Treg的作用机制,并简述调节性T细胞研究面临的挑战与展望.
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| 关 键 词： | 调节性T细胞 CD4^＋CD25^＋Treg D8^＋Treg 免疫抑制 |
| 文章编号： | 1009-2137（2005）06-1137-04 |
| 收稿时间： | 2004-11-19 |
| 修稿时间： | 2005-09-19 |
Mechanism of CD4 + CD25 + and CD8 + Regulatory T cells--Review |
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| OU Yuan,ZHU Ping. Mechanism of CD4 + CD25 + and CD8 + Regulatory T cells--Review[J]. Journal of experimental hematology, 2005, 13(6): 1137-1140 |
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| Authors: | OU Yuan ZHU Ping |
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| Affiliation: | Department of Hematology, The First Hospital of Peking University, Beijing 10034, China. |
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| Abstract: | Regulatory T cells (Treg) play a key role in the negative regulation of the immune system, which can inhibit inappropriate self-reactive T cells, as well as limit the range, extent and lasting time of immune responses, so as to inhibit the proliferation of CD4 and CD8 effector T cells . In view of these properties, there is little doubt about the enormous potential value of Tregs in molecular mechanisms and clinical treatment of human autoimmune disorders, graft-versus-host disease (GVHD) and allergies. In this review, the molecular mechanisms of CD4 CD25 Treg and CD8 Treg were mainly discussed, and challenge with which study on Treg cells is faced and prospects were briefly described. |
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| Keywords: | regulatory T cell CD4 CD25 Treg CD8 Treg immunosuppression |
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