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GNAS-activating mutations define a rare subgroup of inflammatory liver tumors characterized by STAT3 activation |
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| Authors: | Nault Jean Charles Fabre Monique Couchy Gabrielle Pilati Camilla Jeannot Emmanuelle Tran Van Nhieu Jeanne Saint-Paul Marie-Christine De Muret Anne Redon Marie-José Buffet Catherine Salenave Sylvie Balabaud Charles Prevot Sophie Labrune Philippe Bioulac-Sage Paulette Scoazec Jean-Yves Chanson Philippe Zucman-Rossi Jessica |
| Institution: | 1 Inserm, U674, Génomique fonctionnelle des tumeurs solides, Paris, France 2 Université Paris Descartes, Faculté de médecine, Paris, France 3 Assistance Publique-Hôpitaux de Paris, Department of pathology, CHU Bicêtre, France 4 Assistance Publique-Hôpitaux de Paris, Department of pathology, CHU Mondor, Créteil, France 5 Department of pathology, CHU Pasteur, Nice, France 6 Department of pathology, CHU Trousseau, Tours, France 7 Assistance Publique-Hôpitaux de Paris, Department of hepatogastroenterology, CHU Bicêtre, France 8 Assistance Publique-Hôpitaux de Paris, Centre de référence des Maladies Endocriniennes Rares de la Croissance, Department of endocrinology, CHU Bicêtre, Kremlin-Bicêtre, France 9 CHU Bordeaux, Department of hepatogastroenterology, Hopital Saint-André, Bordeaux, France 10 Assistance Publique-Hôpitaux de Paris, Department of pathology, CHU Antoine Béclère, Clamart, France 11 Assistance Publique-Hôpitaux de Paris, Department of pediatrics, CHU Antoine Béclère, Clamart, France 12 CHU Bordeaux, Department of pathology, Hopital Pellegrin, Bordeaux, France 13 Department of pathology, CHU Edouard Herriot, Lyon, France 14 Assistance Publique-Hôpitaux de Paris, Department of oncology, HEGP, Paris, France |
| Abstract: | |
| Keywords: | MCA McCune-Albright syndrome GNAS G-protein alpha stimulatory subunit GTP guanosine-5&prime -triphosphate cAMP cyclic adenosine monophosphate HCA hepatocellular adenoma HNF1A hepatocyte nuclear factor 1A gp130 glycoprotein 130 IHCA inflammatory hepatocellular adenoma HCC hepatocellular carcinoma CTNNB1 β catenin IL6ST interleukine 6 signal transducer cDNA complementary deoxyribonucleic acid SAA serum amyloid A CRP C-reactive protein NESP55 neuroendocrine secretory protein 55 JNK jun N-terminal kinase PKA protein kinase A MAP kinase mitogen activated proteins kinase MRN macroregenerative nodule |
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