新疆某农场病因不明的软骨-骨膜病流行病学调查报告

本文报告了新疆巴楚垦区某农场的一种原因不明的疾病。本病发生在一些地势低洼且饮用水水质很差的地区,临床上主要表现为软骨或骨膜疼痛、硬性隆起。 病区位于洪水泛滥后的低洼地区,土壤为砂质土且盐碱化较重。自1969年居民入居以后即有本病发生,病人离开病区后病情减轻,返回后又加重。重点检查了三个汉族单位、二个维族单位及农场子女学校,受检的1278人中发现174例病人;对农场其他单位也进行了线索调查,确诊了80例病人。汉族单位检出率为16.5％,明显地高于维吾尔族(1.95％),患病无性别差异,病人年龄范围为2～60岁,18岁以前检出率较低(0.7～2.8％),18岁以后检出率迅速上升(27.5～51.1％)。多数病例为1家1例,但亦有2例以上者,最多1家5口人全部患病。51.5％病人在入居后3年内发病,少数人居住不到半年即发病。本病全年均有发病,起病较多月份为4～5月,8～11月发病最少。 对27例作了X线检查,未见骨骼改变。病情较重的汉族单位居民饮用土井水,水质苦咸,含有较多的Ca~(++)、Mg~(++)等无机离子,总盐量多在1.0g/L以上。我们认为本病的致病因子为非生物因子,该因子可能存在于当地的土井水或土壤中。

AN EPIDEMIOLOGICAL INVESTIGATION OF CHONDRO-PERIOSTEAL DISEASE WITH UN KNOWN CAUSES IN A FARM OF BACHU RECLAIMATION AREA, XINJIANG

In this paper, we report a disease which occurred in a farm of Bachu Reclai-mation Area in Xinjinng with unknown causes. Appearing in place with poor quality of drinking water and being characterized clinically by painful and sclerotic eminence of cartilage or periosteum, the disease is called for the present endemic chondro-periosteal disease.The disease area was a flood lowland, with sandy soil rich in salts and alkalies, and was populated in 1969. Since then, the disease has prevailed in inhabitants. Patients with the disease got improved when left the area, but relapses might occur when they returned to the place. Of the 1,278 study subjects in three production teams of Han nationality, two production teams of Uighur nationality and the schools of the farm, 174 were found to have suffered from the disease; the investigation made in other units of the farm led to 80 confirmed cases. The incidence of Han nationality was 16.5%, significantly higher than that of the Uighur (1.95%). No difference in incidence was found between male and female. The age of the patien- ts ranged from 2 to 60 years, the incidence before 18 years of age (0.7~2.8%) was markedly lower than that after 18 years (27.5~51.1%). In most instances, one case occurred in a family, less frequently more than 2 cases in a family, and in one family all of five members were affected. 51.5% of the patients had this malady in 3 years after their entering the area, a few in 6 months. The disease oc curred all year round, with maximum in April-May and minimum in August - No vember.The roentgenograms of 27 cases showed no skeletal changes. The local well wa ter, used as sources of water supply, contained more Ca + + , Mg++ and other inor ganic ions the total amount of salts being for the most part 1.0 g/L and over. In conclusion, the etiologic factors of endemic chondro - periosteal disease may be non-biological ones which may exist in the local well weter or in soil