景天类植物延缓皮肤衰老的实验研究

为了研究景天类植物提取物对延缓皮肤衰老作用 ,采用自身配对设计 ,在 6和 15月龄豚鼠背部皮肤涂抹 0 5 %的景天类植物提取物共 30天。通过组织学观察及生化方法检测丙二醛 (MDA)、超氧化物歧化酶 (SOD)、谷胱甘肽过氧化物酶 (GSH Px)及真皮胶原含量。结果表明 ,涂抹景天类植物提取物的皮肤真皮成纤维细胞明显增多且活跃。皮肤组织SOD及GSH Px活性增高 ,真皮酸溶性胶原中羟脯氨酸含量增加 ,脂质过氧化产物MDA含量减少。提示景天类植物提取物具有良好的延缓皮肤衰老的作用。

Effect of Jingtian compound on the delay of skin aging

In order to study whether Jingtian compound extracted from herbs could delay the process of skin aging, the skin on the back of Guinea pigs (6 and 15 months old) were shaved topically and applied with and without 0 5% Jingtian compound for 30 days by self-control design. The possible alterations caused by Jingtian compound were observed by histological and biochemical techniques. Results showed that the number and the activity of fibroblast in dermis was increased prominently compared with the control. The activities of superoxide dismutase, glutathion peroxidase and the hydroxyproline level of acid soluble collagen in dermis were enhanced, and the malondialdehyde content was inhibited concomitantly. It is suggested that Jingtian compound might play a protective role on skin aging.