Simultaneous temperature and magnetization transfer (MT) monitoring during high‐intensity focused ultrasound (HIFU) treatment: Preliminary investigation on ex vivo porcine muscle |
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| Authors: | Hsu‐Hsia Peng PhD Teng‐Yi Huang PhD Wen‐Yih Isaac Tseng MD PhD En‐Li Lin MS Hsiao‐Wen Chung PhD Chih‐Ching Wu PhD Yu‐Shun Wang MS Wen‐Shiang Chen MD PhD |
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| Affiliation: | 1. Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu, Taiwan;2. Department of Electrical Engineering, National Taiwan University of Science and Technology, Taipei, Taiwan;3. Center for Optoelectronic Biomedicine, National Taiwan University College of Medicine, Taipei, Taiwan;4. Department of Medical Imaging, National Taiwan University Hospital, Taipei, Taiwan;5. Department of Electrical Engineering, National Taiwan University, Taipei, Taiwan;6. Department of Mechanical Engineering, National Taiwan University, Taipei, Taiwan;7. Division of Medical Engineering Research, National Health Research Institutes, Miaoli, Taiwan;8. Department of Physical Medicine and Rehabilitation, National Taiwan University Hospital, Taipei, Taiwan |
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| Abstract: | ![]()
Purpose To measure temperature change and magnetization transfer ratio (MTR) simultaneously during high‐intensity focused ultrasound (HIFU) treatment. Materials and Methods This study proposed an interleaved dual gradient‐echo technique to monitor the heat and tissue damage brought to the heated tissue. The technique was applied to tissue samples to test its efficacy. Results Ex vivo experiments on the porcine muscle demonstrated that both temperature changes and MTR exhibited high consistency in localizing the heated regions. As the heat dissipated after the treatment, the temperature of the heated regions decreased rapidly but MTR continued to be elevated. Moreover, thermal dose (TD) maps derived from the temperature curves demonstrated a sharp margin in the heated regions, but MTR maps may show a spatial gradient of tissue damage, suggesting complimentary information provided by these two measures. Conclusion In a protocol of spot‐by‐spot heating over a large volume of tissue, MTR provides additional values to mark the locations of previously heated regions. By continuously recording the locations of heated spots, MTR maps could help plan the next target spots appropriately, potentially improving the efficiency of HIFU treatment and reducing undesirable damage to the normal tissue. J. Magn. Reson. Imaging 2009. © 2009 Wiley‐Liss, Inc. |
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| Keywords: | temperature magnetization transfer high‐intensity focused ultrasound tissue damage thermotherapy thermal dose |
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