No association between CALHM1 variation and risk of Alzheimer disease |
| |
| Authors: | Ryan L. Minster F. Yesim Demirci Steven T. DeKosky M. Ilyas Kamboh |
| |
| Affiliation: | 1. Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA;2. Department of Neurology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA |
| |
| Abstract: | A polymorphism in the calcium homeostasis modulator 1 gene (CALHM1) has recently been associated with risk of late‐onset Alzheimer disease. We examined this variant (rs2986017) in 945 Caucasian Americans with late‐onset Alzheimer disease and 875 age‐matched Caucasian American controls. No association with risk of late‐onset Alzheimer disease (p=0.368 for genotypes; p=0.796 for alleles) was observed in our sample. However, a potential modest association of minor allele homozygosity (TT) with an earlier age‐at‐onset was seen (p=0.034). © 2009 Wiley‐Liss, Inc. |
| |
| Keywords: | Alzheimer disease CALHM1 genetic association |
|
|
