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Epigenetic Changes in Airway Smooth Muscle as a Driver of Airway Inflammation and Remodeling in Asthma |
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| Authors: | Klaudia A. Kaczmarek Rachel L. Clifford Alan J. Knox |
| Affiliation: | Division of Respiratory Medicine, Nottingham University Hospitals NHS Trust (City Hospital Campus); and the Nottingham NIHR Biomedical Research Centre, Nottingham MRC Molecular Pathology Node |
| Abstract: | |
| Keywords: | airway smooth muscle asthma epigenetics AHR airway hyperresponsiveness ASM airway smooth muscle BET bromodomain and extraterminal DNMTi DNA methyltransferase inhibitor HAT histone acetyltransferase HDAC histone deacetylase miRNA microRNA MMP matrix metalloproteinase ncRNA noncoding RNA phosphodiesterase 4D gene PRMT protein arginine methyltransferase SAHA suberoylanilide hydroxamic acid TNF tumor necrosis factor VCAM-1 vascular cell adhesion molecule-1 VEGF vascular endothelial growth factor |
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