Assessment of mediastinal tumors with diffusion‐weighted single‐shot echo‐planar MRI |
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Authors: | Ahmed Abdel Razek MD Ahmed Elmorsy MD Mohsen Elshafey MD Tamer Elhadedy MD Osama Hamza MD |
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Institution: | 1. Department of Diagnostic Radiology, Mansoura Faculty of Medicine, Mansoura, Egypt;2. Department of Chest, Mansoura Faculty of Medicine, Mansoura, Egypt;3. Cardiothoracic Surgery Department, Mansoura Faculty of Medicine, Mansoura, Egypt |
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Abstract: | Purpose To assess the role of diffusion‐weighted single‐shot echo‐planar magnetic resonance imaging (MRI) in patients with mediastinal tumors. Methods Prospective study was conducted on 45 consecutive patients (29 male, 16 female, age 22–66 years, mean 41 years) with mediastinal tumor. They underwent diffusion‐weighted single‐shot echo‐planar MRI of the mediastinum with a b‐factor of 0, 300, and 600 sec/mm2. The apparent diffusion coefficient (ADC) value of the mediastinal tumor was correlated with the histopathological findings. Results The mean ADC value of malignant mediastinal tumors was 1.09 ± 0.25 × 10?3 mm2/sec, and of benign tumors was 2.38 ± 0.56 × 10?3 mm2/sec. There was a significant difference in the mean ADC value between malignant and benign tumors (P = 0.001) and within different grades of malignancy (0.001). When an ADC value of 1.56 × 10?3 mm2/sec was used as a threshold value for differentiating malignant from benign tumor, the best results were obtained with an accuracy of 95%, sensitivity of 96%, specificity of 94%, positive predictive value of 94%, negative predictive value of 96%, and area under the curve of 0.938. Conclusion The ADC value is a noninvasive parameter that can be used for differentiation of malignant from benign mediastinal tumors and grading of mediastinal malignancy. J. Magn. Reson. Imaging 2009. © 2009 Wiley‐Liss, Inc. |
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Keywords: | diffusion weighted MRI mediastinal tumor |
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