No association between CALHM1 and risk for Alzheimer dementia in a Belgian population |
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| Authors: | Kristel Sleegers Nathalie Brouwers Karolien Bettens Sebastiaan Engelborghs Helen van Miegroet Peter P De Deyn Christine Van Broeckhoven |
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| Affiliation: | 1. Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Belgium;2. Laboratory of Neurogenetics, Belgium;3. University of Antwerp, Belgium;4. Laboratory of Neurochemistry and Behavior, Institute Born‐Bunge, Belgium;5. Memory Clinic and Division of Neurology, ZNA Middelheim, Antwerpen;6. Belgium |
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| Abstract: | A non‐synonymous polymorphism, rs2986017 (p.P86L), in the newly characterized calcium homeostasis modulator 1 (CALHM1) gene located in the Alzheimer dementia (AD) linkage region on 10q24.33, was reported to increase risk of AD, and affect calcium homeostasis and amyloid β accumulation. We aimed to investigate the association between this functional polymorphism and AD in an independent study population. We genotyped rs2986017 in 362 Belgian AD patients and 519 ethnically matched control individuals. We found no evidence of association between rs2986017 and risk of disease, nor did we find an effect on onset age. Despite its functional properties, our study suggests the polymorphism does not contribute significantly to AD risk in the Belgian population. © 2009 Wiley‐Liss, Inc. |
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| Keywords: | Alzheimer disease genetic association CALHM1 calcium homeostasis amyloid β accumulation |
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