Correlation between HIV‐1 seropositivity and prevalence of a γ‐secretase polymorphism in two distinct ethnic populations |
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| Authors: | Karen MJ van Loo Jessica E van Schijndel Martine van Zweeden Daniëlle van Manen Mieke D Trip Desiree C Petersen Hanneke Schuitemaker Vanessa M Hayes Gerard JM Martens |
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| Institution: | 1. Department of Molecular Animal Physiology, Radboud University Nijmegen, Donders Institute for Brain, Cognition and Behaviour and Nijmegen Center for Molecular Life Sciences (NCMLS), Nijmegen, the Netherlands;2. Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands;3. Department of Cardiology, Academic Medical Center, Amsterdam, the Netherlands;4. Cancer Genetics Group, Children's Cancer Institute Australia for Medical Research, University of New South Wales, Randwick, Sydney, New South Wales, Australia;5. Discipline of Medical Virology, Department of Pathology, Faculty of Health Sciences, University of Stellenbosch, Tygerberg, South Africa |
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| Abstract: | Susceptibility for human immunodeficiency virus type 1 (HIV‐1) infection may be influenced by host genetics. Recent findings with a Wistar rat model raised the possibility that the γ‐secretase pathway may be associated with an individual's susceptibility to infection. A functional single‐nucleotide polymorphism (SNP) in the γ‐secretase component APH1B (Phe217Leu; rs1047552) was therefore analyzed for association with HIV‐1 infection. The SNP showed a tendency for association with HIV‐1 infection in a Xhosa indigenous South African Bantu study (P = 0.087), and associated significantly in a Caucasian Dutch study (P = 0.049). Together, the results suggest a role for the γ‐secretase pathway in susceptibility to HIV‐1 infection. J. Med. Virol. 81:1847–1851, 2009. © 2009 Wiley‐Liss, Inc. |
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| Keywords: | AIDS APH1B polymorphism susceptibility gene |
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