Common genetic variants and risk for non‐Hodgkin lymphoma and adult T‐cell lymphoma/leukemia in Jamaica |
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| Authors: | Sophia S. Wang J. Daniel Carreon Barrie Hanchard Stephen Chanock Michie Hisada |
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| Affiliation: | 1. Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Rockville, MD;2. Fax: +301‐402‐0817.;3. Department of Pathology, University of the West Indies, Kingston, Jamaica |
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| Abstract: | We evaluated whether risk of non‐Hodgkin lymphoma (NHL), particularly adult T‐cell leukemia/lymphoma (ATL) related to human T‐lymphotropic virus (HTLV) infection was associated with 63 single nucleotide polymorphisms (SNPs) from 38 candidate genes. The 395 NHL cases registered in Jamaica were matched by age, sex, calendar‐year and HTLV serostatus to 309 controls from the same population. Interleukin 13 (IL13) Ex4+98A>G SNP (rs20541) was associated with decreased NHL risk (ORAG/AA = 0.62,95% CI = 0.44–0.87, p = 0.006), as was vascular cell adhesion molecule‐1, VCAM1 Ex9+149G>A SNP (rs1041163) (ORCT = 0.77, 95% CI = 0.54–1.10, ORCC=0.35, 95% CI = 0.16–0.76, p‐trend = 0.007). Both results were stronger in analyses restricted to ATL cases and HTLV‐positive controls, suggesting a role for these genes in ATL etiology (IL13 ORAG/AA = 0.54, 95% CI = 0.36–0.84, p = 0.005; VCAM1 ORCT = 0.65, 95% CI = 0.42–1.01, ORCC = 0.20, 95% CI = 0.08–0.54, p‐trend = 0.001). Confirmation of these results in Caribbean and other populations is needed. © 2009 UICC |
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| Keywords: | NHL ATL Jamaica HTLV‐I SNP |
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