NK cells from tuberculous pleurisy express high ICAM‐1 levels and exert stimulatory effect on local T cells |
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| Authors: | Pablo Schierloh Noemí Yokobori Laura Geffner Luciana Balboa María M Romero Rosa M Musella Mercedes Alemán Jorge Castagnino Juan Basile Silvia S de la Barrera Eduardo Abbate María C Sasiain |
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| Institution: | 1. Departamento de Inmunología, Instituto de Investigaciones Hematológicas (IIHema), Academia Nacional de Medicina, Argentina;2. División de Tisioneumonología, Hospital F. J. Mu?iz, Buenos Aires, Argentina |
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| Abstract: | Tuberculous pleurisy, one of the most common manifestations of extrapulmonary tuberculosis, is characterized by a T‐cell‐mediated hypersensitivity reaction along with a Th1 immune profile. In this study, we investigated functional cross‐talk among T and NK cells in human tuberculous pleurisy. We found that endogenously activated pleural fluid‐derived NK cells express high ICAM‐1 levels and induce T‐cell activation ex vivo through ICAM‐1. Besides, upon in vitro stimulation with monokines and PAMP, resting peripheral blood NK cells increased ICAM‐1 expression leading to cellular activation and Th1 polarization of autologous T cells. Furthermore, these effects were abolished by anti‐ICAM‐1 Ab. Hence, NK cells may contribute to the adaptive immune response by a direct cell‐contact‐dependent mechanism in the context of Mycobacterium tuberculosis infection. |
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| Keywords: | ICAM‐1 NK cells Pleurisy Th1 Tuberculosis |
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