XRCC3 haplotypes and risk of gliomas in a Chinese population: A hospital‐based case‐control study |
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| Authors: | Keke Zhou Yanhong Liu Haishi Zhang Hongliang Liu Weiwei Fan Yu Zhong Zhonghui Xu Li Jin Qingyi Wei Fengping Huang Daru Lu Liangfu Zhou |
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| Affiliation: | 1. Neurosurgery Department of Huashan Hospital, Fudan University, Shanghai, China;2. Keke Zhou and Yanhong Liu contributed equally to this work.;3. State Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences and Institutes for Biomedical Sciences, Fudan University, Shanghai, China;4. Department of Epidemiology, The University of Texas M.D. Anderson Cancer Center, Houston, TX |
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| Abstract: | In mammalian cells, X‐ray repair cross‐complementing group3 (XRCC3) plays an important role in the DNA double‐strand breaks (DSBs) repair by homologous recombination. Genetic polymorphisms in the XRCC3 gene may potentially affect the repair of DSBs and thus confer susceptibility to gliomas. In this study, we used a haplotype‐based approach to investigate whether 4 tagging single nucleotide polymorphisms of the XRCC3 gene are associated with risk of gliomas in 771 glioma patients and 752 cancer‐free controls. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated by the unconditional logistic regression, and haplotype associations were estimated using Haplo.Stat. After adjustment for age and sex, the variant G allele of rs861530 and T allele of rs3212092 were significantly associated with an increased risk of gliomas (AG/GG versus AA: adjusted OR = 1.44, 95% CI = 1.15–1.80, p = 0.001 and CT/TT versus CC: adjusted OR = 1.66, 95% CI = 1.12–2.46, p = 0.013, respectively). Consistent with these results, XRCC3 haplotype “GGCC” containing rs861530 G allele and haplotype “AGTC” containing rs3212092 T allele were also significantly associated with an elevated risk of gliomas compared with the common haplotype “AGCC” (adjusted OR = 1.35, 95% CI = 1.14–1.58, p = 0.000 and adjusted OR = 1.67, 95% CI = 1.11–2.52, p = 0.015, respectively). Our results suggest that common genetic variants in the XRCC3 gene may modulate glioma risk. © 2009 UICC |
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| Keywords: | DNA repair glioma XRCC3 tagging SNP haplotype‐based association study |
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