Two‐step radiosynthesis of [18F]N‐succinimidyl‐4‐fluorobenzoate ([18F]SFB) |
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Authors: | Matthias Glaser Erik Årstad Sajinder K. Luthra Edward G. Robins |
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Affiliation: | GE Healthcare, Medical Diagnostics, Discovery, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK |
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Abstract: | The acylation reagent [18F]N‐succinimidyl‐4‐fluorobenzoate (18F‐SFB) has been prepared using a new two‐step approach. The starting material p‐[18F]fluorobenzaldehyde (18F‐FBA) was obtained by an improved radiosynthesis with a decay‐corrected radiochemical yield of 66±6 % (n=3). Reaction of 18F‐FBA with (diacetoxyiodine)benzene and N‐hydroxysuccinimide and preparative HPLC purification furnished 18F‐SFB in an r.c.y. of 49±6 % (n=3), based on the starting radioactivity of 18F‐FBA. The radiochemical purity of 18F‐SFB was >99%. Alternatively, purification by solid phase extraction gave 18F‐SFB with an r.c.y. of 77±9% (n=4) and a radiochemical purity of 89±5% (n=4). This radiochemical synthesis only used non‐aqueous solvents, which simplifies the method and facilitates subsequent applications of 18F‐SFB. Copyright © 2009 John Wiley & Sons, Ltd. |
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Keywords: | N‐succinimidyl 4‐fluorobenzoate fluorine‐18 fluorobenzaldehyde PET microwave |
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