| 香丹注射液对冠心病血瘀证内皮源性血管活性因子基因表达的影响 |
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| 引用本文： | 吴时达,王静,陈守春,徐俊波,郑铿,闫亚非,温天明,汤雁蓉. 香丹注射液对冠心病血瘀证内皮源性血管活性因子基因表达的影响[J]. 中西医结合学报, 2004, 2(2): 94-96 |
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| 作者姓名： | 吴时达 王静 陈守春 徐俊波 郑铿 闫亚非 温天明 汤雁蓉 |
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| 作者单位： | 1. 成都市第一人民医院心内科,四川,成都,610016
2. 成都地奥制药集团公司,四川,成都,610041 |
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| 基金项目： | 四川省成都市科技局科技攻关项目 |
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| 摘 要： | 目的:探讨香丹注射液对冠心病患者血瘀证内皮源性血管活性因子基因表达的影响.方法:将56例冠心病血瘀证患者随机分为冠心病常规治疗对照组和常规治疗加香丹注射液治疗组,疗程均为10 d.分别于治疗前、后采血,用RT-PCR方法检测内皮素1(endothelin-1,ET-1)和内皮型一氧化氮合酶(endothelial nitric-oxide synthase,eNOS)的mRNA表达.结果:治疗后,香丹注射液治疗组eNOS的 mRNA阳性率增加,ET-1的 mRNA阳性率下降,两组比较有显著性差异(P<0.05).结论:香丹注射液能调节eNOS和ET-1的mRNA表达,改善冠心病血瘀证患者血管内皮功能.
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| 关 键 词： | 香丹注射液 血管内皮功能 内皮型一氧化氮合酶 内皮素1 |
| 文章编号： | 1672-1977(2004)02-0094-03 |
| 修稿时间： | 2003-06-10 |
Effect of Xiangdan Injection on mRNA expression of endothelial vaso-active factors of patients with coronary heart disease and blood stasis |
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| WU Shi-Da ,WANG Jing ,CHEN Shou-Chun ,XU Jun-Bo ,ZHENG Qiang ,YAN Ya-Fei ,WEN Tian-Ming ,TANG Yan-Rong. Effect of Xiangdan Injection on mRNA expression of endothelial vaso-active factors of patients with coronary heart disease and blood stasis[J]. Journal of Chinese integrative medicine, 2004, 2(2): 94-96 |
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| Authors: | WU Shi-Da WANG Jing CHEN Shou-Chun XU Jun-Bo ZHENG Qiang YAN Ya-Fei WEN Tian-Ming TANG Yan-Rong |
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| Affiliation: | Department of Cardiology, Chengdu First People's Hospital, Chengdu, Sichuan Province 610016, China. |
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| Abstract: | OBJECTIVE: To evaluate the effect of Xiangdan Injection on mRNA expression of the endothelial vaso-active factors of patients with coronary heart disease and blood stasis. METHODS: Fifty-six patients were randomly divided into two groups:twenty-eight patients were treated according to the therapeutic guide for coronary heart disease as the control group and 28 were given the same treatment plus Xiangdan Injection as the treated group. The expressions of ET-1 and eNOS mRNA were examined with RT-PCR before experiment and ten days later. RESULTS: The positive rate of eNOS mRNA of the treated group increased, while the positive rate of ET-1 mRNA of the treated group decreased after ten day's treatment, with significant differences as compared with that before the experiment. Xiangdan Injection up-regulated the eNOS mRNA expression and suppressed the ET-1 mRNA expression. Changes of expression were not observed in the control group. CONCLUSION: Xiangdan Injection improves the endothelial function of patients with coronary heart disease and blood stasis by regulating the expressions of ET-1 and eNOS mRNA. |
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| Keywords: | mRNA |
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