新城鸡瘟病毒修饰自体肿瘤细胞疫苗在28例中晚期宫颈癌的应用

[目的]探讨新城鸡瘟病毒修饰自体肿瘤细胞疫苗（NDV—ATV）存中、晚期宫颈癌治疗中的作用。[方法]28例宫颈癌行NDV-ATV免疫治疗和放射治疗（实验组），30例单纯接受放射治疗（对照组）。采用流式细胞术观察患者存接受免疫治疗前后外周血中CD4^＋、CD8^＋、CD4^＋／CD8^＋比值变化以及放射治疗的近期疗效、毒副反应等。[结果]实验组28例中、晚期宫颈癌患者经治疗1～2个疗程后．其CD4^＋、CD4^＋／CD8^＋比值较治疗前显著增加（P〈0．05），同时CD^8＋数量较治疗前降低（P〈0．05），放射治疗近期疗效较对照组好（P〈0．05），毒副反应轻。[结论]新城鸡瘟病毒修饰自体肿瘤细胞疫苗能增强患者免疫功能．对放射治疗有协同作用。

Application of New castle Disease Virus-Modified Autologous Tumor Vaccine in 28 Cases with Advanced Cervical Carcinoma

Purpose To explore the role of New castle disease virus-modified autologous tumor vaccine(NDV-ATV) for treating advanced cervical carcinoma. Methods Twenty-eight cases with cervical carcinoma underwent NDV-ATV immunotherapy combined with radiotherapy (experimental group),and 30 cases underwent radiotherapy alone(control group). The changes of CD4+,CD8+ and CD4+/CD8+ in the peripherical blood were measured by flow cytometry. Short-term effects of radiotherapy and its side effects were investigated. Results After one to two courses of the therapy for 28 cases with advanced cervical carcinoma,the levels of CD4+ and ratio of CD4+/CD8+ significantly increased than those before treatment (P<0.05),and CD8+ significantly decreased than that before the therapy (P<0.05). The short-term effects of radiotherapy in experimental group was better than that in control group (P<0.05) with mild side effects in former group. Conclusions New castle disease virus-modified autologous tumor vaccine (NDV-ATV) enhances the immunity in cervical carcinoma and synergistically with radiotherapy.