二甲双胍对糖耐量异常患者血浆致动脉粥样硬化指数的影响

目的探讨二甲双胍干预血管动脉粥样硬化的机制。方法糖耐量异常患者60例,随机分为二甲双胍药物（500rag,3次／d）联合生活方式治疗组（A组）和生活方式治疗组（B组）治疗3月,治疗前后分别测空腹血糖（FBG）、餐后2h血糖（PBG）、甘油三脂（TG）、总胆固醇（C）、高密度脂蛋白胆固醇（HDL-C）,并计算血浆致动脉粥样硬化指数（AIP）。结果二甲双胍组治疗3月后PBG、TG、TC、AIP较前均有明显下降,HDL-C水平明显上升。对照组治疗3月后上述指标均未见明显变化。结论二甲双胍联合饮食运动治疗,能明显改善糖耐量异常患者的血糖、血脂、AIP4指标,延缓动脉粥样硬化的进展。

The Response of Atherogenic Index of Plasmato Metformin in Therapy of Impaired Glucose Tolerance Patien

Objective To probe the mechanism of Metformin in intervention the Atherosclerosis.Methods 60 patients with impaired glucose tolerance were randomly divided into Metformin(500mg,3 times a day) combined with lifestyle treatment group(A) and the lifestyle treatment group(B).Treatment is long for 3 months.Before and after treatment we need to measure the fasting blood glucose(FBG),2-hour postprandial blood glucose(PBG),triglyceride(TG),total cholesterol(TC),high density lipoprotein cholesterol(HDL-C),and calculate the AIP.Results After the treatment for 3 months in A group,the PBG,TG,TC,AIP were significantly decreased compared with the previous,HDL-C levels rises.In the B group,there are no significant changes in these indicators.Conclusions Metformin combined with lifestyle treatment can significantly make better glucose tolerance in patients with abnormal blood sugar,blood lipids,AIP targets,delaying the progress of atherosclerosis.