| P物质对变应性鼻炎动物模型鼻粘膜上皮短路电流的影响 |
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| 引用本文： | 刘涛,杨平常.P物质对变应性鼻炎动物模型鼻粘膜上皮短路电流的影响[J].中华耳鼻咽喉科杂志,1998,33(1):32-34. |
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| 作者姓名： | 刘涛 杨平常 |
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| 摘 要： | 目的 观察Ｐ物质（ＳＰ）作用于变应性鼻炎动物模型鼻粘膜引起的离子分泌改变导致的上皮表面短路电流的变化。方法 以鸡蛋清蛋白致敏大鼠后，用Ｕｓｓｉｎｇ室技术测定鼻粘膜上皮表面短路电流。并观察神经激肽受体（ＮＫ１）拮抗剂ＣＰ９６３４５、组胺Ｈ１受体拮抗剂吡拉明、Ｈ２受体拮抗剂雷尼替丁和河豚毒素对ＳＰ的阻断作用。结果 经ＳＰ刺激，致敏大鼠鼻粘膜表面Ｉｓｃ显著增高。经四种物质预处理均能显著阻断ＳＰ引起的Ｉｓ
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| 关 键 词： | 鼻粘膜 P物质 鼻炎 变应性鼻炎 |
Effect of substance P on the short-circuit current of nasal mucosal epithelium] |
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| T Liu,P Yang,B Wang.Effect of substance P on the short-circuit current of nasal mucosal epithelium][J].Chinese Journal of Otorhinolaryngology,1998,33(1):32-34. |
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| Authors: | T Liu P Yang B Wang |
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| Institution: | Department of Otolaryngology, First Affiliated Hospital, Shanxi Medical University, Taiyuan, 030001. |
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| Abstract: | OBJECTIVE: To observe the changes of epithelial apical membrane short-circuit current (Isc) of antigen-sensitized rat nasal mucosa with the stimulation of Substances P (SP). METHODS: The epithelial apical membrane Isc were measured with Ussing chamber technique, and and we observed the blockage to the effect of SP by neurokinin receptor antagonist Cp96345, histamine H1 receptor antagonist pyrilamine, H2 antagonist ranitidine and neurotoxin respectively. RESULTS: The Isc increased significantly with the stimulation of SP. The effect of SP on Isc could be blocked significantly by pretreatment with four substances. CONCLUSION: SP releasing from nervous endings plays the role on elicit a series of pathological changes like enhanced Isc, epithelial permeabilities, etc. |
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