| 大鼠额叶皮层局灶毁损对脾细胞增殖的影响 |
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| 引用本文： | 吴兴辰 邹静. 大鼠额叶皮层局灶毁损对脾细胞增殖的影响[J]. 免疫学杂志, 1997, 13(3): 173-175 |
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| 作者姓名： | 吴兴辰 邹静 |
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| 作者单位： | [1]白求恩国际和平医院神经内科 [2]白求恩国际和平医院耳鼻咽喉科 |
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| 摘 要： | 为了观察额叶皮层对大鼠细胞免疫功能的调控作用，选用雄性Ｗｉｓｔａｒ大鼠，分为左侧额叶皮层毁损组，右侧额叶皮层毁损组，假手术对照组和无创伤对照组，于术后ｄ１９检测其外周血中ＣＤ８＾＋细胞和脾细胞增殖。结果：假手术组与无创伤对照组间外周血ＣＤ８＾＋细胞无显著差异。左、右额叶毁损组外周血ＣＤ８＾＋细胞和脾细胞增殖指数均显著高于假手术组（Ｐ〈０．０１）。结论，额叶皮层毁损可增强机体细胞免疫功能，且左右对称
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| 关 键 词： | 神经免疫调节 细胞免疫 脾细胞增殖 |
THE EFFECT OF FRONTAL CORTEX LESIONS ON PROLIFE RATION OF SPLENOCYTE OF RATS |
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| Wu Xingchen,Zou Jing,Xu Zheng,Li Bin,Bi Aifang,You Guoxiong. THE EFFECT OF FRONTAL CORTEX LESIONS ON PROLIFE RATION OF SPLENOCYTE OF RATS[J]. Immunological Journal, 1997, 13(3): 173-175 |
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| Authors: | Wu Xingchen Zou Jing Xu Zheng Li Bin Bi Aifang You Guoxiong |
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| Abstract: | In order to study the role of frontal cortex in immunomodulation,a cortex lesion experiment was carried out on rats.The male Wistar rats were classified into 4 groups:the left cortexlesioned group,the right cortex lesioned group,the sham operation group and the control group.19 days after cortex destruction operation,the CD8 + rates and splenocyte proliferation were detected.No difference existed between the sham operation group and the control group on CD8 + rates.A significantly increased CD8 + rates and splenocyte proliferation were observed in the left cortex lesioned group and the right cortex lesioned group when compared with the sham operation group( P <0.01).Conclusions:frontal cortex does modulate the cellular immunity in rats,but no laterality changes exist. |
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| Keywords: | Neuroimmunomodulation Brain Cellular immunity |
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