血管内皮生长因子在非小细胞肺癌中的表达及其临床意义

目的研究血管内皮生长因子（VEGF）住非小细胞肺癌（NSCLC）中的表达及其与肿瘤血管形成、临床分期、淋巴结转移的关系。方法 应用免疫组织化学方法和酶联免疫吸附试验检测112例NSCLC患者的肺癌组织和血清中VEGF的表达，并分析其临床意义。结果 NSCLC组织中VEGF中的表达明显高于正常黏膜组织和癌旁组织（p〈）0.01），且大致随临床分期Ⅰ、Ⅱ、Ⅲ-Ⅳ期的顺序明显升高（p〈）0.01）；同时有淋巴结转移组的VEGF水平显著高于无淋巴结转移组（p〈）0.01）。NSCLC患者血清VEGF水平显著高于正常对照组（p〈）0.01），并随肺癌分期Ⅰ、Ⅱ、Ⅲ-Ⅳ期的顺序明显上升（p〈）0.01），淋巴结转移明显高于无淋巴结转移组（p〈）0.01）。结论 VEGF在NSCLC中表达明显增高，并与NSCLC的发生、发展及淋巴结转移有关，血清VEGF是NSCLC增生和转移的重要指标。

Expression and its significance of vascular endothelial growth factor in non-small cell lung cancer

Objective To investigate the relationship between the expression of vascular endothelial growth factor（VEGF） ,and tumor angiogenesis,clinlcal staging,and lymph node metastasis in non-small cell lung cancer（NSCLC）, Methods Immunohistochemical staining and enzyme-linked immunoserbent assay（ELISA） were used to detect the levels of V EGF in the tissue and serum of 112 patients with NSCLC,and their clinical significances were analyzed. Results The expression of VEGF in lung tissue of NSCLC were significantly higher than that in normal alveolar tissue and paracaneerous tissue（ P〈0.Ol ） ,and roughly increased in proportion with clinical stages（ P 〈0.Ol ） ,The positive rates of VEGF in lymph node metastasis group were significantly higher than those without lymph node metastasis group（ P〈 O.Ol ）, Serum VEGF in NSCLC was significantly higher than in the conrad group and also increased in accordance with clinical staging（P〈0.O1）. Serum VEGF was significantly higher in the lymph re,de metastasis group than in the absence group（ P〈O.O1）. Conclusions The expression of VEGF in NSCLC increases signifi cantly, and positively correlates with tumor development, progression and lymph node metastasis. Serum VEGF is an important marker of hyperplasia and metastasis in NSCLC.