| EPO多克隆抗体抑制EPO促CFU-E形成研究 |
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| 引用本文： | 黄学文,牟信兵,高钰琪,李素芝,黄跃,黄文超,陈有,孙泽平,洪勇,石泉贵,郭俊,潘丽,杨定周.EPO多克隆抗体抑制EPO促CFU-E形成研究[J].高原医学杂志,2007,17(3):1-3. |
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| 作者姓名： | 黄学文 牟信兵 高钰琪 李素芝 黄跃 黄文超 陈有 孙泽平 洪勇 石泉贵 郭俊 潘丽 杨定周 |
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| 作者单位： | 第三军医大学高原军事医学系,430038;西藏军区总医院高山病科,850003 |
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| 基金项目： | 拉萨市科技局资助合作项目,项目编号:2004078 |
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| 摘 要： | 目的:探讨EPO多克隆抗体是否具有对抗EPO促红系形成的功能。方法:对大鼠骨髓进行定向体外红系集落形成单位(CFU-E)培养,观察CFU-E数量,判定EPO多克隆抗体对红系增殖活性的影响。结果:与常规培养组比较,EPO多克隆抗体培养组CFU-E明显减少,P<0.01,差别有非常显著性。结论:EPO抗体可抑制EPO促红系形成,其可作为治疗高原红细胞增多症病人的药物进一步研究。
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| 关 键 词： | 促红细胞生成素 抗体 红系集落形成单位 |
The Effects of Polyclonal Antierythropoietin Antibody on Simulating Colony-forming Unit - erythroid |
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| Huang Xuewen,Mu Xinbin,Gao Yuqi,Li Suzhi,Huang Yue,Huang Wenchao,Chen You,Sun Zeping,Hong Yong,Shi Quangui,Guo Jun,Pan Li,Yang Dingzhou.The Effects of Polyclonal Antierythropoietin Antibody on Simulating Colony-forming Unit - erythroid[J].Journal of High Altitude Medicine,2007,17(3):1-3. |
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| Authors: | Huang Xuewen Mu Xinbin Gao Yuqi Li Suzhi Huang Yue Huang Wenchao Chen You Sun Zeping Hong Yong Shi Quangui Guo Jun Pan Li Yang Dingzhou |
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| Institution: | 1 The Third Military Mddical University ,Chongqing,400038; 2. The General Hospital of Tibet Military Command, Lhasa,850000 |
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| Abstract: | Objective:To observe whether the polyclonal antierythropoietin antibody against stimulating colony-forming unit-erythroid(CFU-E) in the cultured marrows from mouse.Methods:Marrows were collected from mouse, they were exposed to Lhasa from Chongqing for 3 months, and the mononuclear cells in the marrows were isolated for erythroid oriented culture. Then the level of CFU-E formation was recorded under the therapeutic condition with erythropoietin (EPO) or EPO and polyclonal antierythropoietin antibody.Results:CFU-E formation was significantly suppressed by polyclonal antierythropoietin antibody.Conclusions:antierythropoietin antibody is able to inhibit the EPO activity stimulating colony-forming unit-erythroid proliferation. |
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| Keywords: | Colony-forming unit-erythroid Erythropoietin High altitude Mouse Polyclonal antierythropoietin antibody |
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