| 两种中药对哮喘大鼠气道壁重构的影响与机制 |
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| 引用本文： | 武永杰,吴世满,刘丽,蔡仁萍.两种中药对哮喘大鼠气道壁重构的影响与机制[J].山西医科大学学报,2008,39(8). |
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| 作者姓名： | 武永杰 吴世满 刘丽 蔡仁萍 |
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| 作者单位： | 山西医科大学第一临床医学院呼吸科,太原,030001 |
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| 基金项目： | 山西医科大学校科研和教改项目 |
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| 摘 要： | 目的 观察黄芩苷、川芎嗪对哮喘大鼠气道壁重构和基质金属蛋白酶-9(MMP-9)及抑制剂-1(TIMP-1)表达的影响.方法 24只Wistar大鼠分为4组:正常对照组,哮喘模型组,黄芩苷组和川芎嗪组.用卵蛋白(OVA)致敏制备大鼠哮喘模型.HE染色测气道壁及平滑肌层厚度,免疫组化染色测定气道壁MMP-9、TIMP-1、Ⅳ型胶原含量.结果 哮喘模型组大鼠气道壁及平滑肌增厚,MMP-9、TIMP-1表达增多,与正常对照组相比差异有统计学意义(P<0.05);黄芩苷组和川芎嗪组大鼠气道壁及平滑肌变薄,MMP-9、TIMP-1表达减少,与哮喘模型组相比差异有统计学意义(P<0.05).结论 黄芩苷、川芎嗪可以通过调节MMP-9/TIMP1比例,减少气道壁胶原沉积和平滑肌增生而降低气道壁厚度.
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| 关 键 词： | 气道重构 黄芩苷 基质金属蛋白酶-9 基质金属蛋白酶抑制剂-1 |
Effect of two herb ingredients on airway remodeling in asthmatic rats |
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| WU Yong-jie,WU Shi-man,LIU Li,CAI Ren-ping.Effect of two herb ingredients on airway remodeling in asthmatic rats[J].Journal of Shanxi Medical University,2008,39(8). |
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| Authors: | WU Yong-jie WU Shi-man LIU Li CAI Ren-ping |
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| Institution: | Dept of Respiration;First Clinical Medical College;Shanxi Medical University;Taiyuan 030001;China |
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| Abstract: | Objective To explore the effect of two herb ingredients(baicalin,ligustrazine)on airway remodeling and the expression of matrix metalloproteinase-9(MMP-9)and tissue inhibitor of metalloproteinase-1(TIMP-1)in asthmatic rats. Methods Twenty-four Wistar rats were randomly divided into four groups:normal control group(n=6),asthmatic model group(n=6),baicalin group(n=6),ligustrazine group(n=6).The rats were sensitized with ovalbumin to establish the asthma model.Lung tissues were sliced and stained with HE.The a... |
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| Keywords: | airway remodeling baicalin matrix metalloproteinase-9 tissue inhibitor of metalloproteinase-1 |
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