消旋卡多曲治疗小儿轮状病毒性肠炎的临床研究

目的：探讨消旋卡多曲治疗小儿轮状病毒性肠炎的临床效果。方法选取本院小儿轮状病毒性肠炎患者96例，随机分为两组，病毒唑治疗患儿48例为对照组，消旋卡多曲治疗患儿48例为观察组，比较两组患儿的病症改善情况、临床疗效、不良反应情况。结果观察组患儿的止吐时间（2.1±0.7）d、止泻时间（2.5±0.9）d、退热时间（1.8±0.6）d、住院时间（4.6±1.3）d均明显小于对照组（2.6±1.0）d、（3.2±1.1）d、（2.3±0.8）d、（6.7±1.5）d，观察组总有效率（97.9%）明显高于对照组（85.4%），观察组不良反应发生率（4.2%）明显低于对照组（16.7%），差异显著（P＜0.05）。结论消旋卡多曲是治疗小儿轮状病毒性肠炎的有效药物，可明显改善患儿的临床病症，缩短治疗时间，临床疗效好且安全性高。

Clinical research of racecadotril in treatment for rotavirus enteritis in children

Objective To investigate the clinical effect of racecadotril in treatment for rotavirus enteritis in children. Methods 96 patients with rotavirus enteritis were selected in hospital, who were randomly divided into two groups. 48 patients treated ribavirin as control group. 48 patients treated racecadotril as observation group. Symptoms improvement situation, clinical efficacy, adverse reactions were compared between two groups. Results Antiemetic time（2.1±0.7）d; antidiarrheal time（2.5±0.9）d; cooling time（1.8±0.6） d; hospitalization time（4.6±1.3）d in observation group were significantly less than control group（2.6±1.0）d, （3.2±1.1）d, （2.3±0.8）d, （6.7±1.5）d. Total effective rate in observation group（97.9%） was significantly higher than control group（85.4%）.Incidence of adverse reactions in observation group（4.2%） was significantly lower than control group（16.7%）. Differences were statistically significant（P〈0.05）. Conclusion Racecadotril is an effective drug in treatment for rotavirus enteritis in children, which can significantly improve clinical symptoms and shorten treatment time.That has good clinical efficacy and high safety.