前列地尔在新生儿肺动脉高压治疗中的效果观察

目的：观察前列地尔在新生儿肺动脉高压治疗中的临床疗效。方法将在我院接受住院治疗的200例新生儿肺动脉高压患者按抽签方法随机分为对照组和治疗组各100例。其中对照组仅采用常频通气治疗，治疗组在常频通气治疗的基础上加用前列地尔治疗。对两组的临床有效率、血气参数、肺动脉收缩压及呼吸机使用时间进行分析比较。结果疗程结束后，治疗组患者的与肺动脉高压有关的各项参数pH、PaO2、PaCO2、SaO2、PASP都明显优于对照组，且两组差异有统计学意义（P＜0.05）。治疗组使用呼吸机的时间仅为（84.5±3.7）h，明显短于对照组（150.3±6.6）h。此外治疗组的总有效率高达99.0%，明显的高于对照组88.0%，差异有统计学意义（P＜0.05）。结论前列地尔对治疗新生儿肺动脉高压有显著的临床疗效，具有临床推广价值。

Clinical effect of alprostadil on pulmonary hypertensio of newborn

Objective To discuss the clinical effect of alprostadil on pulmonary hypertensio of newborn. Methods 200 cases of neonatal pulmonary hypertension patients who were admitted into our hospital were randomly divided into control group （100 cases） and treatment group （100 cases）. The control group was treated with normal frequency ventilation, based on the normal frequency ventilation, the treatment group was treated with alprostadil. Compare and analysis the clinical efficacy, blood gas parameters, pressure of pulmonary artery systolic and ventilation time. Results After treatment, these parameters relevant with pulmonary hypertension such as pH, PaO2, PaCO2, SaO2, PASP in treatment group were significantly high than those in control group, and there was a significant difference between the two groups （P〈0.05）. The Ventilator was used in treatment group just for （84.5±3.7）h, which was significantly shorter than that in control group （150.3±6.6）h.In addition, the total efficiency of treatment group was 99.0%which significantly higher than that in control group （88.0%）, the difference had statistically significant（ P〈0.05）. Conclusion Alprostadil has high clinical effective on the treatment of pulmonary hypertension of newborns and has the value of promotion.