神经梅毒患者18例临床分析

目的：探讨神经梅毒的早期临床表现、不典型临床表现、血清、脑脊液及影像学特征，提高对该病的认识，减少误诊，以便早期治疗，尽量减少并发症的损害。方法对2010年3月～2013年1月期间于我院住院治疗确诊神经梅毒的18例患者临床资料进行回顾性分析。结果18例神经梅毒均予以正规驱梅治疗，随访6个月，其中治愈8例，好转10例。结论神经梅毒临床表现多样复杂、容易误诊、漏诊，足剂量、足疗程的青霉素治疗是预后的关键。建议对于疑似颅内感染、认知功能障碍、精神疾病、不明原因脑梗死的患者进行常规筛查梅毒血清学抗体。

Clinical analysis of 18 cases of neurosyphilis

Objective To improve knowledge of neurosyphilis, reduce misdiagnosis, provide early treatment and reduce complications based on discussion of its early clinical manifestations, atypical clinical manifestations, serum, cerebrospinal fluid and imaging characteristics. Methods Retrospective analysis was applied on the clinical data of 18 patients confirmed with neurosyphilis and given inpatient care in our hospital from March 2010 to January 2013. Results 18 cases of neurosyphilis were given routine treatment and received follow-up visits for 6 months. 8 cases were cured and 10 cases were improved. Conclusion Misdiagnosis and missed diagnosis might occur due to diverse and complex clinical manifestations of neurosyphilis. Treatment with enough penicillin dosage through the course of treatment is critical for prognosis. It is recommended to conduct routine screening of serum syphilis antibodies on patients suspected with intracranial infection, cognitive dysfunction, mental disorders and unexplained cerebral infarction.