尿nephrin与肌酐比率和RBP-4在2型糖尿病肾病诊断中的意义

目的:探讨尿nephrin与肌酐比率(UNCR)和视黄醇结合蛋白4(RBP-4)在2型糖尿病肾病诊断中的意义。方法:选取2型糖尿病患者110例,正常健康对照组40例。采用定量酶联免疫吸附法(ELISA)测定2组患者尿白蛋白、肌酐、nephrin和RBP-4的含量,依据尿白蛋白与肌酐比率(UACR)将糖尿病患者分为正常白蛋白尿组、微量白蛋白尿组和大量白蛋白尿组,进行UNCR与RBP-4相关性分析。结果:正常白蛋白尿组、微量白蛋白尿组和大量白蛋白尿组UNCR比较差异具有统计学意义(P0.05);正常白蛋白尿组UNCR阳性率为51.7%,而微量白蛋白尿组和大量白蛋白尿组UNCR阳性率均大于95%,UNCR与RBP-4呈正相关。正常白蛋白尿组、微量白蛋白尿组和大量白蛋白尿组RBP-4含量比较差异具有统计学意义(P0.05)。结论:UNCR和RBP-4在糖尿病早期诊断和预测糖尿病肾病病情进展中有重要的指示作用。

The Signficance of Urinary Nephrin-Creatinine Ratio and RBP-4in the Diagnosis of Type 2 Diabetic Nephropathy

Objective: To investigate the value of urinary nephrin-creatinine ratio (UNCR) and RBP-4 in the diagnosis of type 2 diabetic nephropathy. Methods: Altogether 110 patients with type 2 diabetes mellitus (DM group) and 40 normal healthy people as the control group were chosen. The contents of urinary albumin, creatinine, nephrin and RBP-4 of the patients in both groups were detected by using ELISA assay, DM group was divided into urinary albumin negative group (DM group), microalbuminuria group and macroalbuminuria group according to UNCR, and the correlation between UNCR and RBP-4 was analyzed. Results: The difference had statistical meaning in the comparisons among DM group, microalbuminuria group and macroalbuminuria group (P＜0.05); UNCR positive rate of DM group was 51.7%, while the rates of microalbuminuria group and macroalbuminuria group were all greater than 95%, which showed that UNCR was positively correlated to RBP-4. The difference had statistical meaning in the comparisons of RBP-4 contents among DM group, microalbuminuria group and macroalbuminuria group (P＜0.05). Conclusion: UNCR and RBP-4 own important indicative function in early diagnosis of DM and predicting DM disease preogression.