117例乳腺癌组织中COX-2和VEGF-C表达及临床意义

目的:分析117例乳腺癌患者癌组织中环氧化酶-2(COX-2)和血管内皮生长因子-C(VEGF-C)表达和两者的相关性,探讨其与临床病理特征,淋巴结转移及预后的关系.方法:收集117例乳腺癌患者的一般情况、临床病理特征和癌组织蜡块,构建乳腺癌组织芯片.应用免疫组化SP法检测COX-2和VEGF-C 的表达. 结果: 117 例乳腺癌组织中COX-2、VEGF-C表达分别为 55.8%、58.1%,且二者呈正相关(r=0.356,P<0.001).COX-2 和VEGF-C的表达均与临床分期、淋巴结转移及有否复发呈正相关,与肿块大小,PR,病理类型,组织学分级无关.COX-2的表达还与ER、Her-2表达呈正相关.结论:COX-2和VEGF-C在乳腺癌组织中均呈高表达且两者呈正相关,检测两者对评估乳腺癌患者的预后有一定的临床意义.

The expressions of cyclooxygenase-2(COX-2) and vascular endothelial growth factor-C (VEGF-C) and their clinical significance in breast cancer tissues of 117 patients

Objective:To analysie the expressions of cyclo-oxygenase-2(COX-2) and vascular endothelial growth factor(VEGF-C) and their relationship in breast cancer tissues of 117 patients,and evaluate their relation to clinical-pathology features,lymphatic metastasis and prognosis. Methods: We collected general information and clinical pathological characters in 117 breast cancer patients,then constructed a tissue array composed of paraffin-embedded carcinomas tissues.The expressions of COX-2 and VEGF-C were detected by IHC SP method. Results: The positive expressions of COX-2 and VEGF-C in the 117 breast cancer tissues were 55.8% and 58.1%,respectively,and they showed direct correlation(r=0.356,P<0.001).The expression of COX-2 and VEGF-C was positive correlated with clinical stage,lymphatic metastasis and recurrence,but there were no correlation with the size of tumor,progesterone receptor,pathology type or histology grade.The expression of COX-2 was also positive correlated with estrogen receptor and Her-2. Conclusion: In breast cancer tissues,COX-2 and VEGF-C were both highly expressed and they showed direct correlation,so examination of their expression would be useful for the evaluation of prognosis in breast cancer.