首发抑郁症及其一级亲属脑基础活动的fMRI研究

目的研究原发性抑郁症患者及其一级亲属脑基础活动的功能磁共振成像（fMRI）表现。方法低频振幅（ALFF）作为评价脑基础活动的生物学指标是利用静态fMRI在下述3组受试者中测量的：1组,原发性抑郁症患者14例;2组,患者的一级亲属14例;3组,作为对照的健康受试者14例。随后,对获自以上3组的ALFF值进行了组间比较。结果患者组左额叶中央前回、左顶叶中央后回、左海与旁回、以及小脑前叶所测得的ALFF值显著低于对照组;患者左扣带前回、左丘脑、以及左小脑前叶脑区所测得的ALFF值显著低于亲属组;亲属组左额中央前回、左额中回脑区所测得的ALFF值也显著低于对照组。结论脑功能区ALFF值显著降低,可能是抑郁症的一个重要fMRI表现。

fMRI study on the spontaneous activity of the brain in primary depression patients and their immediate family members

Objective To study the functional magnetic resonance imaging(fMRI)findings of the spontaneous activity of the brain in paimary depression patients (PDP) and their immediate family members (IFM). Methods amplitude low frequency fluctuation (ALFF) as a biomarker to assess spontaneous activity of the brain was measured by resting state fMRI in following three groups:group 1,PDPs(n=14),group2, IFMs(n=14),and group3,healthy subjects as controls(n=14) and then the ALFF value obtained from above three groups were ...