泌尿生殖道支原体感染状况及药敏分析

目的了解长沙地区男性和女性支原体流行病学情况,建立本地区支原体药敏谱,为临床合理用药提供参考依据。方法利用珠海浪峰生物技术有限公司提供的支原体试剂盒,对1 947例泌尿生殖道感染患者的尿道(宫颈)分泌物标本进行解脲脲原体(Uu)和人型支原体(Mh)培养、鉴定及药敏试验。结果在1 947例疑似病患中,支原体阳性805例,阳性率41.4%,以Uu检出率最高,达22.6%;其次为Uu+Mh混合感染检出率为14.0%;单纯Mh感染检出率最低为4.8%。从性别看,男性阳性率为24.5%,女性阳性率为44.0%,女性感染率明显高于男性。药敏结果表明交沙霉素,强力霉素,美满霉素3种抗菌药物对支原体有较高的抑菌能力,而红霉素的耐药性最高也最普遍。结论长沙地区支原体感染以Uu感染为主,Uu+Mh混合感染也逐年增多。男女性泌尿生殖道支原体(Uu、Mh、Uu+Mh)对常用抗生素药敏谱基本接近,交沙霉素,美满霉素,强力霉素可作为本地区经验性治疗支原体感染的首选抗生素。

Status of mycoplasma infection in urogenital tract and drug sensitivity analysis

Objective To find out the epidemiological situation of mycoplasma infection in men and women in Changsha and to establish the drug sensitivity spectrum of mycoplasma in native area to provide reference for rational clinical drug use.Methods The urinary tract（cervix） secretion samples from 1 947 cases of genitourinary infection were performed the culture,identification and drug sensitivity test for Uu and Mh by using mycoplasma kit.Results In 1 947 suspected cases,mycoplasma positive was in 805 cases with the positive rate of 41.4%.The highest detection rate was in Uu（22.6%）;followed by Uu ＋ Mh mixed infection with the detection rate of 14.0%;Mh infection was the lowest just 4.8%.From a gender perspective,the positive rate was 24.5% in male and 44.0% in female,the infection rate of females was significantly higher than that of males.The drug susceptibility results showed that josamycin,doxycycline and minocycline had the higher antimicrobial activity on mycoplasma,while the highest resistance to erythromycin was highest and most common.Conclusion Mycoplasma infection in Changsha area is mainly Ureaplasma urealyticum（Uu） infection,Uu ＋ Mh mixed infection is also increasing year by year.Mycoplasma（Uu,Mh,Uu ＋ Mh） in male and female urogenital tract infections is close to common antibiotic susceptibility spectrum.Josamycin,minocycline and doxycycline can be used as the first choice of antibiotics in the empirical treatment of mycoplasma infections in this region.