东菱克栓酶治疗不稳定型心绞痛的临床研究 |
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引用本文: | 孙树印,张瑞华,焦华. 东菱克栓酶治疗不稳定型心绞痛的临床研究[J]. 中国中西医结合急救杂志, 2000, 7(5): 300-301 |
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作者姓名: | 孙树印 张瑞华 焦华 |
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作者单位: | 山东省济宁市第一人民医院,山东济宁 |
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摘 要: | 目的:探讨东菱克栓酶(DF-521)治疗不稳定型心绞痛(UA)的疗效及安全性,为临床应用提供依据。方法:75例UA患者于发病后第1,3,5日分别给予DF-5213种剂量:10BU,5BU,5BU,溶于200ml生理盐水中静滴。并选77例UA患者用低分子量肝纱治疗作对照。结果:75例患者经用DF-521治疗后,临床疗效总有效率84.0%,心电图疗效总有效率69.3%,平均起效时间为用药手56小时,复
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关 键 词: | 不稳定型心绞痛 东菱克栓酶 肝素 治疗 |
修稿时间: | 2000-09-02 |
Clinical studies on treatment with batroxobin for unstable angina pectoris |
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Abstract: | Objective:To evaluate the clinically curative effects outcome and security of batroxobin (DF521) on unstable angina pectoris (UAP) in order to provide the evidance for clinical use.Methods:Seventyfive patients with UAP(treated group) were treated with DF521 in dosage of 10,5 and 5 BU dissolved 200 ml normal saline infused intravenously at the first day,the third day and the fifth day respectively.In control group,77 patients with UAP were treated with low molecular weight heparin.Results:After therapy with DF521 in treated group,the improvement rate of clinical symptoms was 84 0%,the effective rate of electrocardiogram was 69 3%,the reaccurrance rate was 21 3%,attack rate of acute myocardial infarction (AMI) within 3 months was 6 6%,the fibrinogen concentration in the blood was decreased significantly compared with low molecular weight heparin treatment group ( P <0 01).The average effective time was 56 hours,and sideeffects such as obvious hemorrhage and allegic reaction were not found.Conclusions:DF521 can be used in treating UAP and is effective,simple and safe. |
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Keywords: | unstable angina pectoris batroxobin low molecular heparin hemorrheology |
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