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A phase 1/2, open-label,dose-escalation study of midostaurin in children with relapsed or refractory acute leukaemia |
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| Authors: | C. Michel Zwaan Stefan Söderhäll Benoit Brethon Matteo Luciani Carmelo Rizzari Ronald W. Stam Emmanuelle Besse Catherine Dutreix Franca Fagioli Phoenix A. Ho Carlo Dufour Rob Pieters |
| Affiliation: | 1. Erasmus MC–Sophia Children's Hospital, Rotterdam, the Netherlands;2. Karolinska Institutet, Stockholm, Sweden Astrid Lindgren Children's Hospital, Stockholm, Sweden;3. Hôpital Universitaire Robert-Debré, Paris, France;4. IRCCS Ospedale Pediatrico Bambino Gesù, Rome, Italy;5. Fondazione MBBM, Azienda Ospedaliera San Gerardo, Monza, Italy;6. Erasmus MC–Sophia Children's Hospital, Rotterdam, the Netherlands Princess Máxima Centre for Paediatric Oncology, Utrecht, the Netherlands;7. Novartis Pharma AG, Basel, Switzerland;8. Paediatric Onco-Haematology, Stem Cell Transplantation and Cellular Therapy Division, A.O.U. Città della Salute e della Scienza di Torino, Ospedale Infantile Regina Margherita, Torino, Italy;9. Seattle Children's Hospital, Seattle, WA, USA;10. Haematology Unit, IRCCS Istituto Giannina Gaslini, Genova, Italy;11. Princess Máxima Centre for Paediatric Oncology, Utrecht, the Netherlands |
| Abstract: | |
| Keywords: | acute leukaemia FLT3 midostaurin paediatric relapsed/refractory |