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Autoantibodies to killer cell immunoglobulin-like receptor 3DL1 in patients with systemic lupus erythematosus |
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| Authors: | A. Doi S. Kano M. Asano Y. Takahashi T. Mimori A. Mimori H. Kaneko |
| Affiliation: | 1. Department of Intractable Diseases, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan;2. Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan Department of Tropical Medicine and Malaria, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan;3. Division of Rheumatic Diseases, Hospital, National Center for Global Health and Medicine, Tokyo, Japan Graduate School of Medical Science, Nagoya City University, Nagoya, Japan;4. Division of Rheumatic Diseases, Hospital, National Center for Global Health and Medicine, Tokyo, Japan;5. Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan |
| Abstract: | A genetic variant of the killer immunoglobulin-like receptor 3DL1 (KIR3DL1) has been found in patients with systemic lupus erythematosus (SLE). Herein, we investigated the presence of autoantibodies to KIR3DL1 in a cohort of patients with SLE. We tested sera from 28 patients with SLE, 11 patients with rheumatoid arthritis (RA) and 17 healthy control subjects for anti-KIR3DL1 activity by an enzyme-linked immunosorbent assay (ELISA) using recombinant KIR3DL1-enhanced green fluorescent protein (EGFP) and EGFP proteins. Anti-KIR3DL1 antibodies were detected in 22 (79%) of the 28 patients with SLE, whereas they were present in only three (27%) of the 11 patients with RA examined. Notably, 10 (91%) of the 11 samples from patients with SLE prior to therapy had anti-KIR3DL1 antibodies. None of the samples from healthy donors were positive for the antibodies. Here, we report the presence of anti-KIR3DL1 antibodies in the sera of patients with SLE for the first time. Anti-KIR3DL1 autoantibodies may be involved in the pathogenesis of autoimmune diseases. |
| Keywords: | autoantibody killer cell immunogloblin-like receptor (KIR)-3DL1 systemic lupus erythematosus |