制药用水系统微生物菌群特性分析及培养探讨

制药用水是药品生产过程中应用最广泛的原料和溶剂，大量用于器具、设备设施和系统的清洗、消毒过程等，参与药品的整个生产过程。制药用水是药品微生物污染的主要源头之一，因此制药用水的微生物安全对药品质量至关重要。本文主要介绍制药用水系统微生物菌群及特性，并进行生物膜分析。因制药用水系统中微生物具有寡养、生长缓慢等特性，本文也进一步探讨制药用水微生物检查方法及培养方法，为建立科学合理的微生物检测体系提供参考，也为深入研究难培养微生物的培养提供思路与理论基础。

Analysis of the Characteristics of Microbial Flora in Pharmaceutical Water Systems and Discussion on Their Cultivation

Pharmaceutical water is the most widely used raw material and solvent in the process of pharmaceutical products, which is widely used in the cleaning and disinfecting process of appliances, equipment, facilities and systems, and is involved in the whole process of pharmaceutical products. Pharmaceutical water is one of the main sources of microbial contamination of pharmaceutical products, so the microbial safety of pharmaceutical water is crucial for pharmaceutical quality. This paper mainly introduces the characterization of the pharmaceutical water system, and conducts biofilm analysis. Due to the characteristics of oligotrophic and slow-growing of microorganisms in the pharmaceutical water system, this paper also further discusses the microbiological testing and culture methods of pharmaceutical water, so as to provide reference for the establishment of a scientific and reasonable microbiological testing system, as well as provide an important theoretical basis and new ideas for further research on hard-to-culture microorganisms.