School of Cancer and Pharmaceutical Sciences, Translational Oncology & Urology Research (TOUR), King's College London, London, UK;3. School of Cancer and Pharmaceutical Sciences, Translational Oncology & Urology Research (TOUR), King's College London, London, UK;4. Department of Urology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden;5. Section 6. of Clinical Geriatrics, NVS- Department, Karolinska Institutet, Karolinska University Hospital, Huddinge, Sweden;7. Department of Surgical Sciences, Uppsala University, Uppsala, Sweden;8. Department of Clinical Science, Intervention and Technology (CLINTEC), Karolinska Institutet, Stockholm, Sweden