多层螺旋CT测量成年贵州小型猪活体肾参考数据

摘要] 目的 通过测量成年健康贵州小型猪肾脏各种径线值及体积，建立贵州小型猪肾脏正常数据。方法 采用西门子双源CT对12头成年健康贵州小型猪（雄性6头，雌性6头）进行薄层容积扫描，原始数据经Aquarius iNtuition 4.4软件进行MRP及VR重组，在横断位正中层面测量双肾前后径及左右径，在冠状位最大面测量双肾长径及短径，计算小型猪体积及双肾体积，双肾长径与短径比值，采用统计学软件对肾长径、长短径比值与肾脏体积，肾脏体积与小型猪体积及体重做相关性分析，p<0.05为差异有统计学意义。结果 左肾前后径及左右径分别为40.40?.67 mm及27.47?.40 mm，长径及短径分别为80.36?.74 mm及31.79?.99 mm，左肾体积为52.78?.25 cm3，左肾长径与短径比值为2.42～2.71：1；右肾前后径及左右径分别为40.95?.43 mm及26.90?.65 mm，长径及短径分别为79.03?.38 mm及32.04?.34 mm，右肾体积为51.91?.25 cm3，右肾长径与短径比值为2.33～2.77：1。双肾长径与肾脏体积呈高度正相关（r左=0.92，P<0.05；r右=0.88，P<0.05），肾脏体积与小型猪体积呈正相关（r左=0.90，P<0.05；r右=0.81，P<0.05），与体重也呈高度正相关（r左=0.96，P<0.05；r右=0.98, P<0.05），但肾脏长短径比值与体积呈负相关（r左=-0.51，P<0.05；r右=-0.67，P<0.05）。结论 多层螺旋CT及其后处理软件可准确测量贵州小型猪活体肾脏的多项影像学数据，为人类肾脏疾病的动物模型研究提供正常参考。

Normal kidney data of adult Guizhou miniature pigs measured by multislice spiral CT in vivo

Objective To establish normal kidney data by measuring the diameter and volume of the kidneys in adult Guizhou miniature pig. Methods Twelve healthy adult Guizhou miniature pigs (male 6, female 6) were used in this study. The kidneys were scanned by using Siemens dual source CT, and the raw data were used for multiplanar reconstruction (MPR) and volume reconstruction (VR) using the software Aquarius iNtuition 4.4. The anteroposterior and left to right dimensions of both kidneys were measured at the median transverse plane of the organ, and the long and short diameters of both kidneys were measured at the maximum coronal section of the organ. The volume of both kidneys and miniature pig itself, the ratio of long to short diameters of both kidneys, and the relationship between the ratio of long to short diameter and the kidney were calculated. The correlation between the length dimension, length diameter ratio and the volume of the kidney was analyzed, and the correlation between volume of the kidney and miniature pig was analyzed as well. P<0.05 was set as statistically significant. Results The dimensions of anteroposterior, left to right, long and short diameters of left kidney were 40.40±1.67 mm, 27.47±1.40 mm, 80.36±2.74 mm and 31.79±1.99 mm, respectively. The volume of left kidney was 52.78±2.25 cm³, and the ratio of long to short diameter of the left kidney was 2.42 to 2.71:1. The dimension of anteroposterior, left to right, long and short diameters of the right kidney were 40.95±1.43 mm, 26.90±0.65 mm,79.03±2.38 mm and 32.04±2.34 mm, respectively. The volume of right kidney was 51.91±2.25 cm³, and the ratio of long to short diameter of the right kidney was 2.33 to 2.77: 1. There were highly positive and significant correlations between the long diameter and the kidney volume (r_left=0.92, P<0.05; r_right=0.88, P<0.05) as well as between the kidney volume and the miniature pig (r_left=0.96, P<0.05; r_right=0.98, P<0.05), while the ratio of long to short diameter of the kidney was negatively related to the volume of the miniature pig (r_left=-0.51, P<0.05; r_right=-0.67, P<0.05). Conclusions Multislice spiral CT and its post-processing software can accurately measure various data of the kidneys of Guizhou miniature pig in vivo, providing normal reference of the animal model for the research of human kidney diseases.