Thermodynamics of Solutions I: Benzoic Acid and Acetylsalicylic Acid as Models for Drug Substances and the Prediction of Solubility |
| |
Authors: | Perlovich German L Bauer-Brandl Annette |
| |
Institution: | (1) Institute of Pharmacy, University of Tromsø, Breivika, N-9037 Tromsø, Norway;(2) Russian Academy of Sciences, Institute of Solution Chemistry, 153045 Ivanovo, Russia |
| |
Abstract: | Purpose. To investigate the solution process of drug substances (exemplified by benzoic acid, BA, and acetylsalicylic acid, ASA), particularly the interrelation between enthalpic and entropic terms of Gibbs energy, in different solvents. To develop an approach for the estimation of standard solution enthalpies based on a self-consistent thermochemical scale.
Method. Two independent methods, solubility experiments (concentrations of saturated solutions) and solution calorimetry (standard solution enthalpies) in aliphatic alcohols and individual organic solvents were used. Correlation between the thermodynamic functions in various solvents were analyzed by standard statistical methods. Multiple regression analysis between H
0
sol values and the parameters of the solvents was run on the Koppel-Palm equation.
Results. Based on experimental data, a compensation effect between thermodynamic functions was observed. Correlation was found between H
0
sol (BA) and H
0
sol (ASA) where the H
0
sol (BA)-values were used as a self-consistent thermochemical scale]. Furthermore, H
0
sol correlated with the Koppel-Palm basicity of the solvents.
Conclusions. The model based on solubility and solution experiments might be useful for the prediction of solubility or solvation of drug substances in different media. The regression equation based on the self-consistent thermochemical scale makes it possible to approximate the ability to solvate a drug substance in comparison with structure-relative substances. |
| |
Keywords: | benzoic acid acetylsalicylic acid solubility solution enthalpy compensation effect alcohols organic solvents |
本文献已被 PubMed SpringerLink 等数据库收录! |
|