| α-细辛脑合成中格式加成反应条件的优化 |
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| 引用本文： | 韦宾,周吴萍,覃旭,黄敬洲,徐岸玲.α-细辛脑合成中格式加成反应条件的优化[J].中国保健营养,2012(4):10-11. |
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| 作者姓名： | 韦宾 周吴萍 覃旭 黄敬洲 徐岸玲 |
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| 作者单位： | 广西亿康药业股份有限公司;广西工学院 |
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| 摘 要： | 目的:通过优化格式加成反应的工艺条件,提高α-细辛脑的收率和稳定产品的质量。方法:采用正交实验设计法,考察了格氏试剂用量、反应时间、反应温度、四氢呋喃用量对α-细辛脑合成产率的影响,优化格式加成反应的工艺条件。结果:按优化条件进行合成,α-细辛脑平均收率达到了64.15%,比原工艺提高了22.35%。结论:优选出的工艺合理可行,重复性好,α-细辛脑的合成产率有所提高。
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| 关 键 词： | α-细辛脑 合成 格式反应 正交设计 |
Optimization of Grignard Addition Reaction Condition for the Synthesis of α-Asarone |
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| WEI Bin,ZHOU Wu-ping,QIN Xu,HUANG Jing-zhou,XU An-ling.Optimization of Grignard Addition Reaction Condition for the Synthesis of α-Asarone[J].China Healthcare & Nutrition,2012(4):10-11. |
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| Authors: | WEI Bin ZHOU Wu-ping QIN Xu HUANG Jing-zhou XU An-ling |
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| Institution: | 1.Guangxi Ecan pharmaceutical Co.Ltd,Liuzhou,Guangxi,545006,China;2.Guangxi University of Technology,Liuzhou,Guangxi,545006,China |
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| Abstract: | Objective:In order to improve the product yield and stability of α-asarone quality,The Grignard addition reaction conditions of α-Asarone synthesis technology were optimized.Methods:The effect of Grignard reagent solvent volume,reaction time,reaction temperature and tetrahydrofuran reagent volume on synthetic yield of α-asarone were studied by the orthogonal design.Results:The average synthesis yield of α-asarone reached 64.15% by using optimum reaction conditions.And it increased by 22.35% than the old process.Conclusion:The optimum synthesis technology is reasonable and feasible.And it has good duplication.The synthesis yield of α-asarone is enhanced. |
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| Keywords: | α-asarone Synthesis Grignard reaction Orthogonal design |
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