多种血清肿瘤标志物在肺癌诊断中的应用价值研究

目的:研究血清癌胚抗原(CEA)、细胞角蛋白19片段21-1(CYFRA21-1)、神经元特异性烯醇化酶(NSE)在肺癌临床诊断中的应用价值。方法:本研究共入选332例研究对象,分为肺癌组(n=112)、肺部良性疾病组(n=132)和健康组(n=88),采用电化学发光免疫分析技术分别检测上述各组患者的血清CEA、CYFRA21-1、NSE水平。结果:肺癌组的血清CEA(ng/ml)、NSE(ng/ml)和CYFRA21-1(ng/ml)水平均较肺部良性疾病组和健康组明显升高,且差异(41.26±22.84 VS 5.89±2.48 VS 2.16±1.2630.12±17.39 VS 15.37±9.48 VS 11.39±6.2121.27±10.36 VS 2.97±1.33 VS 2.02±1.23,P<0.05)。肺癌组血清肿瘤标志物检测阳性率均较肺部良性疾病组明显高(P<0.05)肺腺癌组的CEA检测阳性率(74.55%)较其他组明显高(P<0.05),肺小细胞癌组的NSE的阳性检测率(67.74%)也较其他组明显高(P<0.05)。CEA、CYFRA21-1和NSE三者联合的检测敏感性(96.43%)最高,且与其他肿瘤标志物组合比较具有统计学差异(P<0.05);三者联合检测特异性(80.91%)与其他肿瘤标志物组合相比较没有统计学差异(P>0.05)。肺癌转移组与未转移组血清CEA水平具有统计学差异(31.15±12.48 VS3.12±2.12,P<0.05)。结论:联合血清CEA、CYFRA21-1、NSE具有更高的肺癌诊断价值,血清CEA水平对肺癌转移具有一定的辅助检测价值。

Value of multi-tumor markers protein in diagnosis of lung cancer

Objective To investigate the value of multi-tumor markers protein in the diagnosis of lung cancer.Method Total 332 cases were selected and divided into three groups,lung cancer group(n=112),lung innocence disease group(n=132),and health adults group(n=88).After the treatment,we compared the clinical data between the three groups.Results The level of CEA,NSE and CYFRA21-1 in lung cancer group were higher than those in lung innocence disease group(n=132) and health adults group(P<0.05).The positive detection rate of CEA in adenocarcinoma of the lung group was higher than that of other groups,and the positive detection rate of NSE in small cell lung cancer group was higher than that of other groups,too(P<0.05).The detection sensitivity of combined serum tumor markers(96.43%) was the most highest in all groups(P<0.05).Meanwhile,there was significant difference in the level of CEA between the lung cancer metastasis group and lung cancer non-metastasis group(31.15±12.48 VS 3.12±2.12,P<0.05).Conclusion This study indicates that serum CEA,CYFRA21-1 and NSE are helpful markers for the diagnosis of lung cancer.The combination of the markers can improve the diagnosis of lung cancer.