IL12B基因多态性与卵巢癌的相关性研究

目的:探讨IL12B基因多态性与女性卵巢癌的关系。方法:采用PCR-RFLP技术检测92例卵巢癌患者与38例正常对照者IL12B rs3212227基因多态性。结果:IL12B基因型频率分布在病例组和对照组人群中的差异无统计学意义(p=0.086)。非变异基因型IL12B rs3212227AA与变异基因型IL12B rs3212227AC/CC在两组人群中的分布差异具有显著性(p=0.036),而与AA基因型相比,AC/CC基因型能显著提高卵巢癌的患病风险(OR=2.47;95%可信区间为1.05-5.84)。结论:本研究结果提示,IL12B rs3212227基因多态性与卵巢癌的患病风险有关,其变异提高卵巢癌的发病率,是卵巢癌的危险因子之一。

Association of IL12B Polymorphisms with susceptibility to Ovarian Carcinoma

Objective The aim of this study was to investigate whether IL12B polymorphisms might be associated with increased risk of ovarian carcinoma.Methods We genotyped IL12B rs3212227 by PCR-RFLP in a hospital-based study of 92 ovarian carcinoma cases and 38 cancer-free controls.Results No significant difference was found in frequency distribution of genotypes of IL12B rs 3212227 polymorphisms between cases and controls(P=0.086),while a significant difference was found in frequency distribution of the AA genotype and non-AA genotype between cases and controls(P<0.05),the IL12B rs3212227 AC/CC variant genotypes were associated with a significantly increased risk of ovarian carcinoma odds ratio,2.47;95% confidence interval(CI),1.05-5.84],compared with their corresponding wild-type homozygotes.Conclusion These findings suggest that IL12B rs3212227 polymorphisms may contribute to the risk of ovarian carcinoma,and variant genotypes may increase the incidence of ovarian carcinoma,as a risk factor for ovarian carcinoma.